GDCh-events

GDCh-Kolloquium Professor Dr. Hiroaki Suga

Pseudo-natural peptides, products and neobiologics for therapeutic applications
Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants similar to antibodies), and superior pharmacokinetics.
Zeit
Montag, 04.03.24 - 17:00 Uhr - 18:00 Uhr
Themengebiet
Chemie
Referierende
Professor Dr. Hiroaki Suga, University of Tokyo
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Ort
Chemische Institute - Gerhard-Domagk-Str. 1, 53121 Bonn
Raum
Hörsaal 2
Reservierung
nicht erforderlich
Veranstalter
GDCh Ortsverband Bonn
Kontakt
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