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SUMMARY:OC-Kolloquium: Prof. Dr. A. Ganesan
DTSTART;TZID=Europe/Berlin:20250701T170000
DTEND;TZID=Europe/Berlin:20250701T180000
DTSTAMP:20260518T043939Z
UID:1455b1bec422412fb3dfe62c32c70815@www.chemie.uni-bonn.de
CATEGORIES:oc-events
CREATED:20250305T093737Z
DESCRIPTION:Prof. Dr. A. Ganesan\, University of East Anglia\, Norwich\, U
 K:\n\nEpigenetic Drug Discovery: From Natural Product Total Synthesis to D
 ual Mechanism Inhibitors\n\nThere are three major epigenetic modifications
  that modulate eukaryotic gene transcription: DNA methylation and the meth
 ylation and acetylation of histone proteins. These reversible transformati
 ons are catalyzed by enzymes that have become important targets for drug d
 iscovery and nine ‘epidrugs’ are now approved for clinical use. In thi
 s lecture\, I will describe my group’s efforts in this area beginning wi
 th the total syntheses of histone deacetylase (HDAC) natural product inhib
 itors spiruchostatin A\, romidepsin and azumamides. I will then give recen
 t examples of dual mechanism of action hybrids such as dual HDAC and lysin
 e demethylase inhibitors and dual lysine methyltransferase and demethylase
  inhibitors.
LAST-MODIFIED:20250906T002219Z
URL:https://www.chemie.uni-bonn.de/oc/de/veranstaltungen/copy_of_oc-kolloq
 uium-prof-dr-a-ganesan
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DTSTART:20250330T030000
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