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SUMMARY:David W. Christianson\, University of Pennsylvania
DTSTART;TZID=Europe/Berlin:20231017T170000
DTEND;TZID=Europe/Berlin:20231017T190000
DTSTAMP:20261002T041237Z
UID:56e5d4bb610f4e0aa85ea7cb1f4bf2fd@www.chemie.uni-bonn.de
CATEGORIES:oc-events
CREATED:20230921T105244Z
DESCRIPTION:Directing Biosynthesis with Modular Architecture in Terpene Cy
 clases\nTerpene cyclases catalyze the most complex chemical reactions in b
 iology\, in that more than half of the carbon atoms in an isoprenoid subst
 rate undergo changes in bonding or hybridization during a multi-step cycli
 zation cascade that proceeds through multiple carbocation intermediates. A
 lthough the substrate pool for these enzymes is limited to only a handful 
 of linear isoprenoids\, more than 100\,000 terpenoid natural products have
  been identified to date. Crystal structures of terpene cyclases reveal co
 mmon\, modular protein folds that direct unique catalytic strategies under
 lying this exquisite chemodiversity. Most recently\, structural studies of
  bifunctional assembly-line terpene synthases using cryo-EM and other biop
 hysical techniques show how the first two steps of terpene biosynthesis ar
 e combined in nanoscale oligomeric assemblies.
LAST-MODIFIED:20250906T003243Z
URL:https://www.chemie.uni-bonn.de/oc/de/veranstaltungen/david-w-christian
 son-university-of-pennsylvania
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