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Supramolecular Chemistry

  • Mass spectrometric characterization of labile supramolecular aggregates
  • Gas phase fragmentations
  • Exchange processes in solution and in the gas phase


Major collaboration partners are Prof.Montserrat Ferrer (Barcelona), Prof. Christoph Schalley (Berlin), Prof. Michael Schmittel (Siegen), and Prof. Arne Lützen (Bonn).


Our work in this area includes the project B3 "Mass spectrometric Studies of non-covalent Interactions in the Gas phase and their Contributrion to Template Effects" of the SFB 624 "Templates".


  • Charge-State-Dependent Fragmentation of [2.2]Paracyclophane-Based Metallosupramolecular Cyclic Helicates in the Gas Phase
    J. Anhäuser, A. Lützen, M. Engeser, ChemPlusChem 2020, in press.
    DOI: 10.1002/cplu.202000697
  • A Heterobimetallic Tetrahedron from a Linear Platinum(II)-Bis(acetylide) Metalloligand
    M. Hardy, M. Engeser, A. Lützen, Beilstein J. Org. Chem. 2020, 16,2701-2708.
    DOI: 10.3762/bjoc.16.220
  • Self-Assembled Highly Positively Charged Allyl-Pd Crowns: Cavity-Pocket Driven Interactions of Fluoroanions.
    M. Ferrer, A. Gallen, A. Gutiérrez, M. Martínez, E. Ruiz, Y. Lorenz, M. Engeser, Chem. Eur. J. 2020, 26, 7847-7860.
    DOI: 10.1002/chem.202000316
  • Dynamic Complex-to-Complex Transformations of Heterobimetallic Systems Influence the Cage Structure of Spin State of Iron(II) Ions
    M. Hardy, N. Struch, J. J. Holstein, G. Schnakenburg, N. Wagner, M. Engeser, J. Beck, G. H. Clever, A. Lützen, Angew. Chem. Int. Ed. 2020, 59, 3195-3200.
    DOI: 10.1002/anie.201914629
  • [2.2]Paracyclophane bis(pyridine)-based metallosupramolecular rhombs in the gas phase: Competitive cleavage of non-covalent and weak covalent bonds
    Y. Lorenz, J. Anhäuser, A. Lützen, M. Engeser, J. Am. Soc. Mass Spectrom. 2019, 30, 2007-2013.
    DOI: 10.1007/s13361-019-02218-2
    open access - view-only version
  • Subcomponent self-assembly of a cyclic tetranuclear Fe(II) helicate in a highly diastereoselective self-sorting manner
    J. Anhäuser, R. Puttreddy, L. Glanz, A. Schneider, M. Engeser, K. Rissanen, A. Lützen, Chem. Eur. J. 2019, 25, 12294-12297.
    DOI: 10.1002/chem.201903164
  • Chiral hydrogen-bonded supramolecular capsules: synthesis, characterization and complexation of C70
    M. Kohlhaas, M, Zähres, C. Mayer, M. Engeser, C. Merten, J. Niemeyer, Chem. Commun. 2019, 55, 3298-3301.
    DOI: 10.1039/c8cc10152c
  • Chiral self-sorting behaviour of [2.2]paracyclophane-based bis(pyridine) ligands
    J. Anhäuser, R. Puttreddy, Y. Lorenz, A. Schneider, M. Engeser, K. Rissanen, A. Lützen, Org. Chem. Front. 2019, 6, 1226-1235.
    DOI: 10.1039/C9QO00155G
  • Bond dissociation energies of metallosupramolecular building blocks: Insight from fragmentation of selectively self-assembled heterometallic metallo-supramolecular aggregates
    Y. Lorenz, A. Gutiérrez, M. Ferrer, M. Engeser, Inorg. Chem. 2018, 57, 7346-7354.
    DOI: 10.1021/acs.inorgchem.8b00930
  • An Octanuclear Metallosupramolecular Cage Designed To Exhibit Spin-Crossover Behavior
    N. Struch, C. Bannwarth, T.K. Ronson, Y. Lorenz, B. Mienert, N. Wagner, M. Engeser, E. Bill, R. Puttreddy, K. Rissanen, K. Beck, S. Grimme, J.R. Nitschke, A. Lützen, Angew. Chem. Int. Ed. 2017, 56, 4930-4935.
    DOI: 10.1002/anie.201700832
  • Enantiomerically Pure Trinuclear Helicates via Diastereoselective Self-Assembly and Characterization of their Redox Chemistry
    C. Gütz, R. Hovorka, N. Struch, J. Bunzen, G. Meyer-Eppler, Z.-W. Qu, S. Grimme, M. Cetina, F. Topić, K. Rissanen, M. Engeser, A. Lützen, J. Am. Chem. Soc. 2014, 136, 11830-11838.
    DOI: 10.1021/ja506327c
  • Kinetico-Mechanistic Insights on the Assembling Dynamics of Allyl-Pd Metallamacrocycles; the Pt-Npy bond is the Keystone
    I. Angurell, M. Ferrer, A. Gutiérrez, M. Martínez, M. Rocamora, L. Rodríguez, O. Rossell, Y. Lorenz, M. Engeser, Chem. Eur. J. 2014, 20, 14473-14487.
    DOI: 10.1002/chem.201403467
  • Self-assembly of metallosupramolecular rhombi from chiral concave 9,9'-spirobifluorene-derived bis(pyridine) ligands
    R. Hovorka, S. Hytteballe, T. Piehler, G. Meyer-Eppler, F. Topić, F. Rissanen, M. Engeser, A. Lützen,  Beilstein J. Org. Chem. 2014, 10, 432-441.
    DOI: 10.3762/bjoc.10.40
  • Enantiomerically Pure M6L12 or M12L24-Polyhedra from Flexible Bis(Pyridine) Ligands
    C. Gütz, R. Hovorka, C. Klein, Q.-Q. Jiang, C. Bannwarth, M. Engeser, C. Schmuck, W. Assenmacher, W. Mader, F. Topić, F. Rissanen, S. Grimme, A. Lützen,  Angew. Chem. Int. Ed.  2014, 53, 1693-1698.
    DOI: 10.1002/anie.201308651

  • Electron capture dissociation of a self-assembled tetranuclear metallosupramolecular complex in the gas phase
    R. Hovorka, M. Engeser, A. Lützen,  Int. J. Mass Spectrom.  2013, 354, 152-158.
    DOI: 10.1016/j.ijms.2013.07.002

  • Heteroleptic Metallosupramolecular Racks, Rectangles and Trigonal Prisms:  Stoichiometry-Controlled Reversible Interconversion
    S. Neogi, Y. Lorenz, M. Engeser, D. Samanta, M. Schmittel, Inorg. Chem. 2013, 52, 6975-6984.
    DOI: 10.1021/ic400328d

  • Implications of Stoichiometry-Controlled Structural Changeover Between Heteroleptic Trigonal [Cu(phenAr2)(py)]+ and Tetragonal [Cu(phenAr2)(py)2]+ Motifs for Solution and Solid-State Supramolecular Self-Assembly.
    S. Neogi,  G. Schnakenburg, Y. Lorenz, M. Engeser, M. Schmittel, Inorg. Chem.  2012, 51, 10832-10841.
    DOI: 10.1021/ic301286w
  • Self-Assembly of heterometallic metallomacrocycles via ditopic Fluoroaryl Gold(I) Organometallic Metalloligands.
    M. Ferrer, A. Gutiérrez, L. Rodríguez, O. Rossell, E. Ruiz, M. Engeser, Y. Lorenz, R. Schilling, P. Gómez-Sahl, A. Martín, Organometallics 2012, 31, 1533-1545.
    DOI: 10.1021/om201028q

  • 3D Au-Ag heterometallic supramolecular cage. Triplet capture by heavy atom effect.
    L. Rodríguez, J.C. Lima, M. Ferrer, O. Rossell, M. Engeser, Inorg. Chim. Acta 2012, 381, 195-202.
    DOI: 10.1016/j.ica.2011.09.038

  • Implications of Stoichiometry-Controlled Structural Changeover Between Heteroleptic Trigonal [Cu(phenAr2)(py)]+ and Tetragonal [Cu(phenAr2)(py)2]+ Motifs for Solution and Solid-State Supramolecular Self-Assembly.
    S. Neogi,  G. Schnakenburg, Y. Lorenz, M. Engeser, M. Schmittel, Inorg. Chem.  2012, 51, 10832-10841.
    DOI: 10.1021/ic301286w

  • Antisymbiotic Self-Assembly and Dynamic Behavior of Metallamacrocycles with Allylic Corners
    I. Angurell, M. Ferrer, A. Gutiérrez, M. Martínez, L. Rodríguez, O. Rossell, M. Engeser, Chem. Eur. J. 2010, 16, 13960-13964.
    DOI: 10.1002/chem.201002605

  • Magnetic coupling in enaniomerically pure trinuclear helicate-type complexes formed by hierarchical self-assembly
    M. Albrecht, M. Fiege, P. Kögerler, M. Speldrich, R. Fröhlich, M. Engeser, Chem. Eur. J. 2010, 16, 8797-8804.
    DOI: 10.1002/chem.200903108

  • Cap for Copper(I) Ions! Metallosupramolecular Solid and Solution State Structures on the Basis of the Dynamic Tetrahedral [Cu(phenAr2)(py)2]+ Motif
    M. Schmittel, B. He, J. Fan, J.W. Bats, M. Engeser, M. Schlosser, H. Deiseroth, Inorg. Chem. 2009, 48, 8192-8200.
    DOI: 10.1021/ic900657w

  • Characterization of Self-assembled Metallodendrimers in Liquid and Gas Phase and at Air-Solid Interfaces
    H. T. Baytekin, M. Sahre, M. Engeser, A. Rang, A. Schulz, C. A. Schalley, Small 2008, 4, 1823-1834.
    DOI: 10.1002/smll.200800135
    highlighted in: Materials Views

  • Synthesis of Axially Chiral [4,4’]-Bipyridines and their Remarkably Selective Self-Assembly into Chiral Metallo-Supramolecular Squares
    A. Rang, M. Engeser, N.M. Maier, M. Nieger, W. Lindner, C.A. Schalley, Chem. Eur. J. 2008, 14, 3855-3859.
    DOI: 10.1002/chem.200800113

  • Self-assembly reactions between N-blocked metal corners (N-N)M(II) (N-N = ethylenediamine, 4,4'-substituted 2,2'-bipyridine; M = Pd, Pt) and the fluorinated edge 1,4-bis(4-pyridyl)tetrafluorobenzene
    M. Ferrer, A. Gutiérrez, M. Mounir, O. Rossell, E. Ruiz, A. Rang, M. Engeser, Inorg. Chem. 2007, 46, 3395-3406.
    DOI: 10.1021/ic062373s

  • Mass Spectrometry as as Tool in Dendrimer Chemistry: From Self-Assembling Dendrimers to Dendrimer Gas-Phase Host-Guest Chemistry
    C. A. Schalley, B. Baytekin, H. T. Baytekin, M. Engeser, T. Felder, A. Rang, J. Phys. Org. Chem. 2006, 19, 479-490.
    DOI: 10.1002/poc.1105

  • Reactivity of Self-Assembled Supramolecular Complexes in the Gas Phase: A Supramolecular Neighbor Group Effect
    M. Engeser, A. Rang, M. Ferrer, A. Gutierrez, H. T. Baytekin, C. A. Schalley, Int. J. Mass Spectrom. 2006, 255/256, 185-194.
    DOI: 10.1016/j.ijms.2006.01.002

  • Gas-phase H/D exchange of the protonated serine octamer cluster: "ion ping pong" of populations A and B
    U. Mazurek, M. Engeser, C. Lifshitz, Int. J. Mass Spectrom. 2006, 249/250, 473-476.
    DOI: 10.1016/j.ijms.2005.11.006

  • Solid phase synthesis of a double 4-pyridinyl terminated Leu-Ala-Leu tripeptide and macrocyclization by palladium(II) coordination.
    M. Albrecht, P. Stortz, M. Engeser, C. A. Schalley, Synlett 2004, 2821-2823.
    DOI: 10.1055/s-2004-835624


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