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The Biophysical Chemistry Workgroup



Our work group is devoted to the analysis of molecular dynamics in the context of biological or biomimetical systems; our core area is the analysis of molecular kinetics within supra-molecular complexes on the single molecule level.

We employ state-of-the-art light microscopy techniques like confocal scanning microscopy and single-molecule microscopy using different illumnation techniques.

Our labs are equipped for the preparatory biochemistry and all standard protocols from cell to molecular biology.

A further key aspect of our work is the development of new or the improvement of existing light microscopic methods; current emphases are light sheet fluorescence microscopy (LSFM), confocal LSFM and 3D particle tracking.

Recent Publications:


Press release August 4th, 2022:

Lastenaufzug hilft Bakterien, eine Tarnkappe zu bauen: Bakterieller Membrantransporter unterstützt Krankheitserreger, sich vor dem Immunsystem zu verstecken

Der Transport von Substanzen über die Membran in die Zelle ist an spezifische Membrantransportproteine gebunden. Forschern des Universitätsklinikums Bonn (UKB) und der Universität Bonn ist es nun in Zusammenarbeit mit einem internationalen Team gelungen, die molekulare Struktur einer ganz neuen Klasse von solchen Membrantransportern aufzuklären. Beteiligt waren neben den Bonner Wissenschaftlern auch Forscher der Universität York. Die Studie ist jetzt im Fachmagazin Nature Communications erschienen.

[Vollständige Presseerklärung]


Press release Okt 27, 2021

Researchers film
fundamental life process:

Study by the University of Bonn shows how the machines that build proteins are transported out of the nucleus
Image © Dr. Jan Ruland, AG Kubitscheck / University of Bonn

All proteins in a cell are assembled by complicated molecular machines. The precursors of these ribosomes are produced in the cell nucleus and then enter the cell through the so-called nuclear pores. Researchers at the University of Bonn and ETH Zurich have now filmed this fundamental process in living cells for the first time. Their experiments improve the understanding of how ribosomes are created. The study is published in the journal Nature Communications.

[Video from the publication]


[Press release]



Press release Mar 20, 2020

The mode of action of daptomycin : Research group of the University of Bonn
solves a 30-year-old puzzle

One of the last arrows in the quiver in the fight against dangerous bacteria is the reserve antibiotic daptomycin. It is used primarily when conventional drugs fail due to resistant bacteria.
Although the antibiotic was developed around 30 years ago, its exact mode of action was previously unclear. Scientists at the University of Bonn have now deciphered the puzzle: Daptomycin blocks the integration of important building blocks into the cell wall of the pathogens, thereby killing the bacteria.

The results have now been published in the journal "Nature Communications".

Bild ©  Fabian Grein [Pressemitteilung] [Press release]



The editors at Nature Communications have put together an Editors’ Highlights webpage of recent research on Therapeutics
and one of the editors, Sonja Schmid, has chosen to feature our article there.