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The Biophysical Chemistry Workgroup

3D-Tracking

mRNA-Export


Our work group is devoted to the analysis of molecular dynamics in the context of biological or biomimetical systems; our core area is the analysis of molecular kinetics within supra-molecular complexes on the single molecule level.

We employ state-of-the-art light microscopy techniques like confocal scanning microscopy and single-molecule microscopy using different illumnation techniques.

Our labs are equipped for the preparatory biochemistry and all standard protocols from cell to molecular biology.

A further key aspect of our work is the development of new or the improvement of existing light microscopic methods; current emphases are light sheet fluorescence microscopy (LSFM), confocal LSFM and 3D particle tracking.

  


Recent Publication:
 

Press release Mar 20, 2020
The mode of action of daptomycin : Research group of the University of Bonn
solves a 30-year-old puzzle
Strep_Dapto_PM

One of the last arrows in the quiver in the fight against dangerous bacteria is the reserve antibiotic daptomycin. It is used primarily when conventional drugs fail due to resistant bacteria.
Although the antibiotic was developed around 30 years ago, its exact mode of action was previously unclear. Scientists at the University of Bonn have now deciphered the puzzle: Daptomycin blocks the integration of important building blocks into the cell wall of the pathogens, thereby killing the bacteria.

The results have now been published in the journal "Nature Communications".

Bild ©  Fabian Grein [Pressemitteilung] [Press release]
   

 

Addendum:

The editors at Nature Communications have put together an Editors’ Highlights webpage of recent research on Therapeutics
and one of the editors, Sonja Schmid, has chosen to feature our article there.
 

 


 

 

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