GDCh-events

GDCh Kolloquium - Professor Dr. Jieping Zhu

Catalytic Enantioselective Pictet-Spengler Reaction of Ketones: Development and Applications in the Total
Synthesis of Indole Alkaloids

The asymmetric Pictect-Spengler reaction (PSR) between tryptamine and aldehydes is now well-developed. Conversely, catalytic enantioselective PSR of ketone is essentially unexploited. In this presentation, we will present our work on the catalytic enantioselective PSR of tryptamine with 1,2-diones, α-ketoesters and α-ketoamide for the synthesis of enantioenriched 1,1-Disubstituted tetrahydro-β-carboline (THBC) and their application in the total synthesis of monoterpene indole alkaloids.
Zeit
Dienstag, 20.06.23 - 17:00 Uhr - 18:00 Uhr
Themengebiet
Chemie
Referierende
Professor Jieping Zhu
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Ort
Chemische Institute - Gerhard-Domagk-Str. 1, 53121 Bonn
Raum
Hörsaal 2
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nicht erforderlich
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GDCh Ortsverband
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