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Zukünftige Termine

Events die der OC oder GDCh zuzuordnen sind.

  • 2025-07-08T17:15:00+02:00
  • 2025-07-08T19:00:00+02:00
Juli

8

Dienstag

08.07.2025 von 17:15 bis 19:00

Prof. Dr. Giovanni Appendino, Università del Piemonte Orientale, Novara, Italy: The lab is a curious place. Things that shaped chemistry and you would not believe could have happened there

  • 2025-07-15T10:00:00+02:00
  • 2025-07-15T11:00:00+02:00
Juli

15

Dienstag

15.07.2025 von 10:00 bis 11:00

Prof. Dr. A. Ganesan, University of East Anglia, Norwich, UK: Total Synthesis – The First Fifty Years The total synthesis of complex natural products was revolutionised by Corey’s invention of retrosynthetic analysis in the 1960s. But how was total synthesis performed in the pre-Corey era? Willstatter’s 1901 route to tropinone involved six alkene formations and nearly 20 steps is very different from Robinson’s 1917 one step three component synthesis. I will discuss the inspiration for Robinson’s work and how it was applied by others such as Corey and Heathcock for iminium ion cascade reactions. We will then compare Woodward’s 1944 quinine synthesis with modern approaches to the alkaloid.

  • 2025-07-15T17:00:00+02:00
  • 2025-07-15T18:00:00+02:00
Juli

15

Dienstag

15.07.2025 von 17:00 bis 18:00

Prof. Dr. A. Ganesan, University of East Anglia, Norwich, UK: Epigenetic Drug Discovery: From Natural Product Total Synthesis to Dual Mechanism Inhibitors There are three major epigenetic modifications that modulate eukaryotic gene transcription: DNA methylation and the methylation and acetylation of histone proteins. These reversible transformations are catalyzed by enzymes that have become important targets for drug discovery and nine ‘epidrugs’ are now approved for clinical use. In this lecture, I will describe my group’s efforts in this area beginning with the total syntheses of histone deacetylase (HDAC) natural product inhibitors spiruchostatin A, romidepsin and azumamides. I will then give recent examples of dual mechanism of action hybrids such as dual HDAC and lysine demethylase inhibitors and dual lysine methyltransferase and demethylase inhibitors.