Prof. Rafael Gramage-Doria, University of Rennes 1:
Homogeneous metal Catalysis: from sustainable transformations to supramolecular approaches

The generation of more efficient, atom- and step-economy transformations is of primary importance to meet the societal challenges associated the 21st century. In this context, transition metal catalysis is an enabling technology and, in our laboratories, we have developed a number of sustainable approaches dealing with C-H bond functionalizations, one-pot multi-step sequences, direct reductive aminations, amongst others. They aim at minimizing chemical wastes while controlling metal’s reactivity. On another hand, we have developed metal-catalyzed transformations which are controlled by remote, kinetically labile interactions taking place in the secondary coordination sphere of the metal catalyst.